Table 3.
DRD2 in CRC
| System | Agents/targets | Results/effect | |
|---|---|---|---|
| Mouse xenograft model | Metoclopramide | Antiproliferation | [39] |
| Rat colon cancer model | Haloperidol | Cancer cell growth↓ | [40] |
| Human colon tissue | Dopamine receptor | Receptor and CRC linked | [41] |
| Human | SNP study | DRD2 and CRC linked | [42] |
| Human colon tissue | L-DOPA decarboxylase | Cancer biomarker | [43] |
| Human colon tissue | DARPP-32 | Cancer biomarker | [44] |
| Human colon tissue | DARPP-32 functional study | DARPP-32↑PI3K/Akt, growth↑ | [45] |
| CRC cell lines (HCT116, LoVo, HCT15, and HT29) | Chlorpromazine | Apoptosis | [46] |
| HCT116 cells | Thioridazine | Cancer stem cell autophagy | [47] |
| HT29, HCT116, RKO, LoVo, CT26, and SW480 cells/Mice | Thioridazine | CRC cell autophagy | [48] |
| HCT116 cells | Domperidone | ERK/STAT3↓ cell death | [49] |
| Human/animal | Vanoxerine | CRC stem cell↓ | [50] |