Table 4.
Cellular Effects of DRD2 antagonists
| Compound | Cancer cells | Effects | Reference |
|---|---|---|---|
| Thioridazine | Cancer stem cells from HCT116 | Antitumor effect | [47] |
| Thioridazine | Cervical carcinoma SiHa | Cell death | [53] |
| Thioridazine | Triple-negative breast cancer cells | STAT3 inhibition | [21] |
| Thioridazine | Cervical cancer | Akt, PI3K inhibition | [54] |
| Thioridazine | Leukemia cell | mitochondrial Apoptotic pathway | [55] |
| Haloperidol | Glioblastoma | ERK signaling↑ | [58] |
| Domperidone | Triple-negative breast Cancer cells | ROS, JAK/STAT3 Signaling↑ | [60] |
| Domperidone | Small cell lung cancer cells | Cell growth↑ | [35] |