FIG. 4.

T-cell recognition of ARV resistance mutations V82A and L10I in subject 23. (A) CD8 T-cell responses to the V82A 17-mer peptide but no T-cell recognition of the wild-type V82V peptide or ARV resistance mutation V82T or I84V peptides. (B) CD8 T-cell response to L10I 17-mer peptide but not to L10L wild-type peptide. (C) The response to L10I was mapped to the adjacent 9-mers QI9 and RG9 at 1 μg/ml (Table 4), but a titration study at lower peptide concentrations showed the response was strongest to the L10I-QI9 epitope.