TABLE 4.
Fine mapping of CD8 T-cell response spanning L63P and L10I mutations
| Peptide sequence (peptide)a | CD8+ IFN-γ response (%) at peptide concn (μg/ml)b:
|
|
|---|---|---|
| 1 | 10 | |
| KVRQYDQIPIEICGHKA(L63P) | 0.14 | |
| KVRQYDQIP | 0.00 | |
| VRQYDQIPI | 0.00 | 0.00 |
| RQYDQIPIE | 0.01 | 0.00 |
| QYDQIPIEI(QI9) | 0.07 | 0.12 |
| YDQIPIEIC | 0.00 | 0.00 |
| DQIPIEICG | 0.00 | 0.00 |
| QIPIEICGH | 0.00 | |
| IPIEICGHK | 0.00 | |
| PIEICGHKA | 0.00 | |
| QITLWQRPIVTIKIGGQ(L10I) | 0.07 | |
| QITLWQRPI | 0.02 | |
| ITLWQRPIV | 0.03 | |
| TLWQRPIVT | 0.03 | |
| LWQRPIVTI | 0.02 | |
| WQRPIVTIK | 0.04 | |
| QRPIVTIKI(QI9) | 0.17 | |
| RPIVTIKIG(RG9) | 0.14 | |
| PIVTIKIGG | 0.01 | |
| IVTIKIGGQ | 0.04 | |
a
Boldface type indicates the amino acid mutation.
b
Boldface numbers indicate positive responses.