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. 2024 Sep 27;15:8390. doi: 10.1038/s41467-024-52703-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 5 — a Male C57Bl/6 N mice administered with adeno-associated viruses expressing a microRNA to silence Sec22b (miR-Sec22b) with re-expressing of Sec22b cDNA (Sec22b-WT or Sec22b-S137A) or a AAV control (miR-NC & Gfp). The mice were acutely treated with either saline (VEH) or acyl-glucagon (GCG) (n = 3/group). Co-immunoprecipitation proteomics analysis of the liver lysates was then conducted. VENN diagram summarizes the amount of proteins interacting with SEC22B under the different conditions (enriched proteins: Log2 > 4, FDR < 0.05). b Functional enrichment analysis of 20 proteins which exclusively bounded with SEC22B (in Sec22b-WT + Glucagon group). c Gene ontology enrichment analysis of glucagon induced proteins bound with SEC22B-WT protein (Sec22b-WT + GCG/Sec22b-WT + VEH). d Gene ontology enrichment analysis of glucagon induced proteins bound with SEC22B-S137A mutant proteins (Sec22b-S137A + GCG/Sec22b-WT + VEH). For enrichment analysis, g:GOSt tool was used on the gProfiler web server to perform functional enrichment. g:GOSt utilizes Fisher’s one-tailed test and applies multiple testing correction by default.