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. 2005 Jun 7;33(10):3224–3234. doi: 10.1093/nar/gki638

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Strand bias of operons and individually transcribed genes in B.subtilis (above) and E.coli (below). We asked whether genes in multi-gene operons (‘op’) showed greater bias than genes not in operons (‘not’). We examined essential (‘E’) and non-essential (‘N’) genes separately and also show the combined results (‘either’). We analyzed both operon predictions (left) and known operons (right). Error bars show 95% confidence intervals for the proportion of genes in each category on the leading strand (from the binomial test). Significant differences between operons and singletons are marked with ‘**’ (P < 0.005, Fisher's exact test) or ‘*’ (P < 0.05, Fisher's exact test). The horizontal dashed line at 0.5 indicates equal proportions of genes on the leading and lagging strands, or no bias.