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. 2005 Jul;79(13):8131–8141. doi: 10.1128/JVI.79.13.8131-8141.2005

FIG. 7.

FIG. 7.

Influence of MHC class I allele on NAb titers and SIV-specific CD8+ T-cell responses in monkeys vaccinated with live attenuated SIVmac239Δ3. (A) Comparison of median NAb titers in Mamu-A*01− and Mamu-A*01+ monkeys. Bars indicate medians. (B) Comparison of SIV-specific CD8+ cellular immune responses in Mamu-A*01+ and Mamu-A*01− animals by IFN-γ ELISPOT assay. CD8-enriched lymphocytes were assessed by an IFN-γ ELISPOT assay using Gag, Env, Rev, Vif, Tat, and Nef peptide pools. The sums of the total responses against all peptide pools used are shown. Bars indicate medians. (C) Correlation of SIV-specific CD8+ spot-forming cells and NAb titers (TCLA SIV251 assay) in vaccinated monkeys prior to challenge.