Table 1.

Schedule of events.

	Screening	Intervention start, T=0 week	T + 3 weeks (±7 days)	T + 7 weeks (±7 days)	T + 11 weeks (±7 days)	T + 20 weeks (±7 days)	T + 20 weeks (±7 days)	T + 21 weeks (± 7 days)
Visit	V1	V2	V3	V4	V5	V6aa	V6ba	V7
Medical history and physical exam	X					X
Vitals, anthropometric measurements	X	X	X	X	X	X	X
Clinical labs	X					X
Randomization		X
DXAb scan	X					X
ECGc	X
SPPBd, grip strength, 6-minute walk	X					X
Surveys (SF-12e, CNAQf)	X					X
Blood, muscle, and adipose biopsy		X					X
Start of semaglutide for treatment group		X
Semaglutide dispensed to treatment group		X	X	X	X
Lifestyle education		X	X	X	X
Assessment of adverse events		X	X	X	X	X	X	X

^aVisits 6a and 6b are the end-of-study visits but are split into 2 visits.

^bDXA: dual-energy x-ray absorptiometry.

^cECG: electrocardiogram.

^dSPPB: short physical performance battery.

^eSF-12: Short-Form 12.

^fCNAQ: The Council on Nutrition Appetite Questionnaire.