| 1 Mean percent change in lesion counts at cycle 6 |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.1 Mean percent change in total lesion count |
1 |
173 |
Mean Difference (IV, Fixed, 95% CI) |
29.08 [3.13, 55.03] |
| 1.2 Mean percent change in inflammatory lesion count |
1 |
146 |
Mean Difference (IV, Fixed, 95% CI) |
14.61 [5.18, 24.04] |
| 1.3 Mean percent change in non‐inflammatory lesion count |
1 |
146 |
Mean Difference (IV, Fixed, 95% CI) |
19.03 [5.13, 32.93] |
| 1.4 Mean percent change in papule count |
1 |
146 |
Mean Difference (IV, Fixed, 95% CI) |
17.33 [5.60, 29.06] |
| 1.5 Mean percent change in pustule count |
1 |
125 |
Mean Difference (IV, Fixed, 95% CI) |
1.73 [‐11.48, 14.94] |
| 1.6 Mean percent change in nodule count |
1 |
62 |
Mean Difference (IV, Fixed, 95% CI) |
0.83 [‐8.80, 10.46] |
| 1.7 Mean percent change in open comedone count |
1 |
141 |
Mean Difference (IV, Fixed, 95% CI) |
‐14.28 [‐84.76, 56.20] |
| 1.8 Mean percent change in closed comedone count |
1 |
145 |
Mean Difference (IV, Fixed, 95% CI) |
20.79 [3.57, 38.01] |
| 2 Clear or almost clear (investigator assessment) at cycle 6 |
2 |
575 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
3.02 [1.99, 4.59] |
| 3 Participants classified as 'improved' at cycle 6 |
1 |
|
Peto Odds Ratio (Peto, Fixed, 95% CI) |
Subtotals only |
| 3.1 Investigator assessment |
1 |
152 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
3.67 [1.46, 9.20] |
| 3.2 Participant assessment |
1 |
152 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
3.06 [1.06, 8.85] |
| 4 Discontinuation |
3 |
|
Peto Odds Ratio (Peto, Fixed, 95% CI) |
Subtotals only |
| 4.1 Due to adverse event |
3 |
1251 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
1.57 [0.94, 2.62] |
| 4.2 Due to reason other than adverse event |
1 |
179 |
Peto Odds Ratio (Peto, Fixed, 95% CI) |
0.71 [0.28, 1.84] |
