| Methods |
Multicenter trial in 8 European countries. Double blind but no mention of who was blinded. Pretreatment wash‐out period not stated. 9 treatment cycles. |
| Participants |
425 women of reproductive age with mild to moderate acne and seborrhea. Exclusion criteria not stated. |
| Interventions |
Group 1: Cyproterone acetate (CPA) 2 mg plus ethinyl estradiol (EE) 35 µg
Group 2: CPA 2 mg plus EE 50 µg |
| Outcomes |
Healing or improvement of acne cases from baseline. |
| Notes |
Methods of randomization and allocation concealment were not described. No mention of early discontinuation. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
Placebo group received identical‐appearing tablets. |
