| Methods |
Multicenter open trial in Brazil.
Pretreatment wash‐out was not described.
6 treatment cycles. |
| Participants |
595 healthy women of fertile age with regular ovulatory cycles. Excluded women with contraindications to oral contraceptives, breast feeding or regular use of drugs that impair the efficacy of oral contraceptives. |
| Interventions |
Group 1: DSG 150 µg plus EE 30 µg
Group 2: Gestodene (GSD) 75 µg plus EE 30 µg |
| Outcomes |
Acne severity score ("absent" no acne lesions; "mild" < 6 comedones or papules; "moderate" 6‐15 comedones or papules and < 4 inflamed lesions; "severe" > 15 comedones or papules and > 3 inflamed lesions).
Early discontinuation due to side effects. |
| Notes |
Methods of randomization and allocation concealment were not described.
94 women were excluded, discontinued early or were lost to follow‐up. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
No information |
