| Methods |
Multicenter, open trial in Thailand.
Pretreatment washout period was not described.
6 treatment cycles. |
| Participants |
783 healthy women of fertile age with regular cycles. No specific age range was reported. Excluded women with contraindications to oral contraceptives, complete breast feeding or regular use of drugs that impair oral contraceptives. |
| Interventions |
Group 1: DSG 150 µg plus EE 30 µg
Group 2: GSD 75 µg plus EE 30 µg |
| Outcomes |
Acne lesion counts.
Acne severity grades ("absent" no acne lesions; "mild" < 6 comedones or papules; "moderate" 6‐15 comedones or papules and/or < 4 inflamed lesions; "severe" > 15 comedones or papules and/or > 3 inflamed lesions).
Early discontinuation due to side effects. |
| Notes |
Randomization by random number tables. No information on allocation concealment. 104 women were excluded, discontinued early or were lost to follow up. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
No information |
