TABLE 3.

ICP27 mutants

Class and mutant	Regiona affected	Replicationb	Reference(s)
Deletion
d27-1	Δ1-512	D	74
C-terminal truncation
n59r	Δ60-512	D	74
n504r	Δ505-512	D	74
In-frame deletion
dLeu	Δ6-19	I	51
d1-5	Δ13-153	D	59
d1-2	Δ12-63	I	71
d2-3	Δ64-109	C	6
d3-4	Δ109-138	C	59
d4-5	Δ139-153	D	59
d5-6	Δ154-173	C	59
d6-7	Δ174-200	C	6
Point mutation
m11	aa340, 341	D	75
vBSLG4	aa480	Cc	81, 87

^aAmino acid (aa) residues deleted.

^bBased on plaquing ratio (Vero/V27) (4, 29). D, defective for growth on Vero cells; I, inefficient growth on Vero cells; C, competent for growth on Vero cells.

^cAt 33.5°C.