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The substrate envelope of EV68-3C protease. A heatmap representation of the calculated dynamic substrate envelope for EV68-3C protease shows the percent occupancy of viral substrates within this three-dimensional volume. The peptide backbone is most well conserved between the P4 and P2′ positions and has more variability at P5 and at P3′. The percent occupancy ranges from lowest (dark blue) to highest (red) of finding atoms at that position within a given viral peptide.
