Table 7.
Meta-analysis of the prevalence of Oropouche Virus isolates among subjects from the general population (i.e., without documented signs/symptoms of ongoing arbovirus infection).
| Testing | No. of Series | No. of Observations | No. of Events | Detection Rate (%, 95%CI) | I2 (95%CI) | Tau2 | Q | p-Value |
|---|---|---|---|---|---|---|---|---|
| Serology, IgG | ||||||||
| Overall | 8 | 3344 | 1083 | 24.45 (7.83 to 55.21) | 97.6% (96.5 to 98.3) | 3.548 | 287.63 | <0.001 |
| ELISA | 2 | 1616 | 338 | 59.82 (22.71 to 88.29) | 99.5% | 1.357 | 198.31 | |
| ELISA (on HAT) | 5 | 1523 | 635 | 29.31 (21.91 to 37.99) | 92.6% | 0.176 | 54.26 | |
| ICT | 1 | 205 | 0 | 0.0 (0.00 to 100) | - | - | - | |
| Serology, IgM/IgG | ||||||||
| Overall | 4 | 753 | 12 | 1.42 (0.61 to 3.28) | 41.9% (0.0 to 80.5) | 0.251 | 5.17 | 0.160 |
| HAT | 1 | 0.67 (0.17 to 2.64) | - | - | - | |||
| PRT | 3 | 2.16 (0.99 to 4.68) | 6.2% | 0.018 | 2.13 | |||
Note: I2 = percent proportion of variance in study estimates that is due to heterogeneity; tau2 = estimate of variance of underlying distribution of true effect sizes; Q = weighted sum of squared differences between individual study effects and pooled effect across studies; 95%CI = 95% confidence interval; RT-qPCR = real-time quantitative polymerase chain reaction; ICT = immunochromatography; ELISA = enzyme-linked immune assay; HAT = hemagglutination test; PRT = plaque reduction neutralization test.