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. 2024 Sep 9;16(9):1436. doi: 10.3390/v16091436

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Plaque-picked isolates from Patients 2 and 3 show the accumulation of mutations during prolonged SARS-CoV-2 replication in the patients. RNA-sequencing results from plaque-picked SARS-CoV-2 virus working stocks used for characterization work in this paper (UTR, untranslated region; S, Spike; E, envelope; M, matrix; N, nucleocapsid). All mutations are relative to the 2020 Wuhan-Hu-1 reference genome (NCBI Reference Sequence: NC_045512.2). For comparison to nasal swab sequences from [9], see Supplementary Tables S2 and S3.