TABLE 2.
Prevalence of detection of HIV-1-specific IFN-γ ELISPOT responses during the first year of life of 61 HIV-1-infected infants
| Age (months) | No. tested (% of cohort) | Prevalence of HIV-1-specific responses [no. of positive infants/no. of infants infected (%)]
|
P valueb | |
|---|---|---|---|---|
| In uteroa | Peripartum | |||
| 1 | 33 (54) | 7/12 (58) | 6/21 (29) | .09 |
| 3 | 45 (74) | 12/18 (67) | 14/27 (52) | .4 |
| 6 | 41 (67) | 6/15 (40) | 13/26 (50) | .4 |
| 9 | 29 (48) | 6/11 (54) | 8/18 (44) | .5 |
| 12 | 26 (43) | 5/10 (50) | 10/16 (63) | .6 |
a
The timing of infection of infants was categorized as in utero if HIV-1 DNA or RNA was detected in dried blood spots or plasma collected within the first 48 h of life. Infants were categorized as infected peripartum if HIV-1 DNA or RNA was undetectable within the first 48 h. of life and detectable at 1 month of life.
b
P values determined by Pearson's chi-square statistic.