FIG. 8.
Histological examination of lung tissues from transgenic mice deficient in perforin, FasL, or both cytolytic pathways and infected with influenza virus. F5-RAG-1−/− (a, e, i, and m), F5-RAG-1−/−-P−/− (b, f, j, n, and n′), F5-RAG-1−/−-FasL−/− (c, g, k, and o), or F5-RAG-1−/− -P−/−-FasL−/− (d, h, l, and p) mice were infected with 104 PFU of A/Mem. Lungs taken on day 2 (A), day 5 (B), day 9 (C), or day 15 (D) were stained with hematoxylin and eosin and subjected to gross and microscopic pathological analysis. Original magnification, ×200.