Fig. 3.

The double-edged role of RNA m6A modification in tumor progression. Two primary mechanisms regulate the progression of tumors: modulation of the expression levels of oncogenes and tumor suppressor genes. RNA m6A regulators promote tumor cell proliferation by activating the NOTCH signaling pathway and targeting downstream oncogenes, such as c-Myc, CXCR4, and SOX2. Alternatively, the activation of tumor suppressor genes, including P53, HINT-2, and PERP, or the reduction of oncogene expression in tumor cells can impede the development of tumors. Consequently, the m6A regulators are the primary mechanism responsible for the implementation of m6A modifications that regulate tumor growth in a variety of tumor-specific, cellular, or environmental contexts. This figure was created with BioRender.com