TABLE 4.
cDNA microarray analyses of human oral mucosa (keratinocytes) exposed to extracellular HIV-1 Tat and GST protein as a control
| Gene | % Increase in gene expression |
|---|---|
| PCTAIRE protein kinase 3 (apoptosis related) | −1.3a |
| Cyclin C | 18.5 |
| Mitogen-activated protein kinase (MAPK) 7 | 2.4 |
| E2F transcription factor 5 (transcription activators and repressors) | −62.0 |
| Cyclin-dependent kinase inhibitor | 28.0 |
| Transcription factor Dp-2 | 17.8 |
| Caspase 9 (apoptosis related) | 30.0 |
| Caspase 10 (apoptosis related) | 25.0 |
| Proline dehydrogenase (oxygenase) | 31.0 |
| TNF receptor superfamily member 12 | 17.6 |
| Insulin-like growth factor 1 | 27.0 |
| Insulin-like growth factor binding protein 6 | 9.0 |
| Retinoid X receptor beta (nuclear receptor, death receptor) | 34.0 |
| Ras homolog gene family member A | 22.0 |
a
Negative (−) signs indicate genes that were down-modulated.