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The enhancing effects of methylphenidate were blocked by co-administration of the dopamine D1 receptor antagonist, SCH23390 at doses which had no effect on their own. Results represent mean ± S.E.M. percent correct on the delayed alternation task. VEH = cracker vehicle; MPH = optimal dose of methylphenidate (1.0–3.0 mg/kg); SCH = SCH23390 (0.01 or 0.1 mg/kg); ** significantly different from VEH p = 0.0002; † significantly different from MPH, p = 0.008.
