Table 2.

P-scores for comparison between treatments for efficacy, benefit-risk and quality of life (QoL). Drugs are ranked by P-score for each endpoint.

Endpoint	Placebo	Modafinil 200 mg	Modafinil 400 mg	Pitolisant	Solriamfetol
Efficacy Z-score (ESS + OSLER/MWT)	0.00	0.48	0.47	0.78	0.76
Ranking	5	3	4	1	2
ESS	0.01	0.57	0.57	0.63	0.73
Ranking	5	3	3	2	1
OSLER/MWT	0.03	0.51	0.62	0.66	0.69
Ranking	5	4	3	2	1
Benefit-risk (efficacy/safety)	0.00	0.32	0.56	0.81	0.67
Ranking	5	4	3	1	2
QoL	0.27	0.25	0.69	0.73	0.66
Ranking	4	5	2	1	3

For each parameter, a P-score highlighted in yellow signifies a significant one-sided benefit of a treatment compared with a blue-highlighted treatment: a P-score closer to 1 indicates relative superiority.

ESS, Epworth Sleepiness Scale; MWT, maintenance of wakefulness test; OSLER, Oxford Sleep Resistance test, QoL, quality of life.