Fig. 3.

Circulation and targeting ability of macrophage membrane (Møm)-coated Prussian blue (PB) nanoparticles (MPB NPs) in the apolipoprotein E knockout (ApoE^−/−) mice after i.v. administration. (A) Fluorescence images of indocyanine green (ICG)-labeled PB (PB^ICG) NPs and ICG-labeled Møm-coated PB (MPB^ICG) NPs in the serum at different time points. (B) Pharmacokinetic curves of PB^ICG NPs and MPB^ICG NPs in C57BL/6 mice. (C, D) The fluorescence images (C) and quantitative analysis (D) of the aortas of ApoE^−/− mice. (E, F) The fluorescence images (E) and quantitative analysis (F) of the major organs excised from the ApoE^−/− mice. Data are means ± standard deviation (SD) (n = 3). ^∗P < 0.05 vs. the PB^ICG group. PBS: phosphate-buffered saline; t_1/2: half-life.