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. 2024 Jan 13;14(9):100937. doi: 10.1016/j.jpha.2024.01.005

Fig. 4.

Fig. 4

The efficacy of macrophage membrane (Møm)-coated rosuvastatin (RVS)-loaded Prussian blue (PB) nanoparticles (MPR NPs) in apolipoprotein E knockout (ApoE−/−) mice fed a high methionine diet (HMD). (A, B) Oil red O (ORO) staining (A) and quantitative analysis (B) of the aorta (n = 3). (C, D) ORO staining (C) and quantitative analysis (D) of aortic root. (E–H) ORO staining: the images (E) and quantitative analysis (F) of aortic arch, and the images (G) and quantitative analysis (H) of abdominal aorta. (I–K) The assay of total cholesterol (TC) (I), triglyceride (TG) (J), and Hcy (K) levels in the ApoE−/− mice serum (n = 3). (L–O) Hematoxylin/eosin (H&E) staining (L) and quantitative analysis (M) of aortic root, and Masson's trichrome (N) and quantitative analysis (O) of aortic root. Data are means ± standard deviation (SD) (n = 3). ##P < 0.01 and ###P < 0.001 vs. the control group; ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 vs. the HMD. ns: no significance.