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. 2024 Jan 13;14(9):100937. doi: 10.1016/j.jpha.2024.01.005

Fig. 9.

Fig. 9

Macrophage membrane (Møm)-coated rosuvastatin (RVS)-loaded Prussian blue (PB) nanoparticles (MPR NPs) improve the intestinal microenvironment in apolipoprotein E knockout (ApoE−/−) mice fed high methionine diet (HMD). (A, B) Simpson (A) and Shannon indexes (B) for the control, HMD, and HMD + MPR groups. (C) Principal coordinate analysis (PCoA) plots show the differences between the control, HMD, and HMD + MPR groups. (D) The non-metric multidimensional scaling (NMDS) plot for reflecting the ordering relationship of the values in the distance matrix. (E) Venn diagram showing the co-existing gut microbiota among the control, HMD, and HMD + MPR groups. (F) The columns plot species abundance at the microbial phylum level among the control, HMD, and HMD + MPR groups. (G) Ternary phase diagram of genera from the top 10 most abundant phylum among the control, HMD, and HMD + MPR groups. (H) Evolutionary tree of genus level in the control, HMD, and HMD + MPR groups. (I) The columns plot species abundance at the microbial genus level among the control, HMD, and HMD + MPR groups. (J) Ternary phase diagram of genera from the top 10 most abundant genus among the control, HMD, and HMD + MPR groups. (K, L) Linear discriminant analysis (LDA) scores (K) from linear discriminant analysis effect size (LEfSe) analyses (L) were analyzed for taxa with the highest differential abundance and among the control, HMD, and HMD + MPR groups (n = 4). Detailed meanings of all code names in Fig. 9L are shown in Table S1. PC: principal component; MDS2: multidimensional scaling 2.