Table 5.
Association of postoperative red blood cell transfusion volume with risk of the composite outcome in patients with preoperative anemia, stratified by perioperative hemoglobin decrease (ΔHb).
| Patients with ΔHb <30 % | |||
|---|---|---|---|
| Units transfused (no. patients) | Composite outcome n (%) | Unadjusted odds ratio (95 % confidence interval) | Adjusted odds ratioa (95 % confidence interval) |
| 0.0 (467) | 113 (24.2) | 1 (reference) | 1 (reference) |
| 0.1–2.0 (187) | 22 (11.8) | 0.42 (0.26–0.68) | 0.47 (0.27–0.82) |
| 2.1–4.0 (104) | 11 (10.6) | 0.37 (0.19–0.72) | 0.41 (0.20–0.84) |
| 4.1–6.0 (52) | 14 (26.9) | 1.15 (0.60–2.21) | 0.91 (0.43–1.95) |
| >6.0 (41) | 19 (46.3) | 2.71 (1.41–5.18) | 1.99 (0.91–4.35) |
| P for trend |
0.314 |
0.947 |
|
| Patients with ΔHb ≥ 30 % | |||
| 0.0 (n = 542) |
191 (35.2) |
1 (reference) |
1 (reference) |
| 0.1–2.0 (n = 174) | 40 (23.0) | 0.55 (0.37–0.81) | 0.91 (0.58–1.41) |
| 2.1–4.0 (n = 149) | 35 (23.5) | 0.56 (0.37–0.86) | 0.71 (0.44–1.15) |
| 4.1–6.0 (n = 83) | 30 (36.1) | 1.04 (0.64–1.68) | 1.10 (0.64–1.91) |
| >6.0 (n = 71) | 37 (52.1) | 2.00 (1.22–3.29) | 1.94 (1.08–3.50) |
| P for trend | 0.137 | 0.102 | |
a
Adjusted for sex, age (<65, ≥65 year), body mass index (<18.5, 18.5–24.9, 25.0–29.9 and ≥ 30.0 kg/m2), current smoking, ASA classification, comorbidities (see section 3.2 in main text), preoperative hemoglobin, postoperative nadir hemoglobin (<7.0, ≥7.0 g/dL), left ventricular function, type of surgery, cardiopulmonary bypass duration, and intraoperative red blood cell transfusion.