Table 2.

Gene-editable targets for enhancing anti-solid tumor activity within CD8⁺ T cells

Targets	Physiological effect in T cell	Gene editing	Tumor	Efficacy	Clinic trial	Reference
SOCS1	Inhibiting cytokine reactivity	KO	Melanoma in mice	Suppressing tumor growth	Advanced solid tumors (NCT06237881)	[228]
Regnase-1/Roquin-1	Inhibiting inflammatory phenotype	KO	Melanoma in mice	Improving survival rate	N/A	[231]
PTPN2	Inducing differentiation of exhausted phenotype	KO	Melanoma in mice	Suppressing tumor growth	N/A	[150]
RASA2	Inhibiting TCR antigen sensitivity	KO	Melanoma in mice	Improving survival rate	N/A	[234]
P38	Inhibiting the differentiation of effector phenotype	KO	Melanoma in mice	Improving survival rate	N/A	[236]
ARID1A	Inducing the occurrence of terminal exhaustion phenotype	KO	Melanoma in mice	Suppressing tumor growth	N/A	[237]
CBLB	Inhibiting proximal TCR signaling	KO	Colon carcinoma in mice	Suppressing tumor growth	N/A	[345]
CD5	Inhibiting proximal TCR signaling	KO	Pancreatic carcinoma in mice	Suppressing tumor growth	N/A	[346]
PRODH2	Inducing immune metabolic remodeling	KI or OE	Breast carcinoma in mice	Suppressing tumor growth	N/A	[238]
CARD11-PIK3R3	Inducing effector and memory phenotype differentiation	KI or OE	Melanoma in mice	Improving survival rate	N/A	[239]

KO: Knock-out, KI: Knock-in, OE: Overexpression, N/A: Not Applicable