Table 2.
Univariate and multivariate analyses of factors associated with overall survival in the Triple-negative group
| characteristic | Overall Survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Univariable analysis | Multivariable analysis I a | Multivariable analysis IIb | |||||||
| HR 1 | 95%CI 1 | P-value | HR 1 | 95%CI 1 | P-value | HR 1 | 95%CI 1 | P-value | |
| Age | |||||||||
| ≤ 60 | REF | ||||||||
| > 60 | 1.011 | 0.535–1.910 | 0.973 | ||||||
| Sex | |||||||||
| male | REF | ||||||||
| female | 0.974 | 0.473–2.007 | 0.943 | ||||||
| ECOG scores | |||||||||
| 0 | REF | REF | REF | ||||||
| 1/2 | 2.034 | 1.070–3.868 | 0.030 | 1.984 | 1.018–3.870 | 0.044 | 2.048 | 1.052–3.985 | 0.035 |
| ypT | |||||||||
| 0–2 | REF | REF | REF | ||||||
| 3 | 6.362 | 2.048–19.767 | 0.001 | 8.202 | 2.150-32.284 | 0.002 | 8.714 | 2.261–33.591 | 0.001 |
| 4 | 7.367 | 1.954–27.784 | 0.003 | 8.447 | 2.483–28.734 | 0.001 | 9.121 | 2.623–31.719 | 0.002 |
| ypN | |||||||||
| 0 | REF | REF | REF | ||||||
| 1 | 1.077 | 0.409–2.839 | 0.881 | 1.227 | 0.435–3.458 | 0.699 | 1.326 | 0.464–3.791 | 0.599 |
| 2 | 2.829 | 1.197–6.687 | 0.018 | 2.665 | 1.092-6.500 | 0.031 | 2.399 | 0.974–5.909 | 0.057 |
| 3 | 3.632 | 1.532–8.614 | 0.003 | 2.928 | 1.189–7.209 | 0.019 | 2.866 | 1.155–7.108 | 0.023 |
| Location | |||||||||
| upper | REF | ||||||||
| middle | 0.866 | 0.428–1.967 | 0.825 | ||||||
| lower | 0.689 | 0.441–2.255 | 0.994 | ||||||
| mixed | 0.978 | 0.412–2.338 | 0.974 | ||||||
| LVI | |||||||||
| no | REF | ||||||||
| yes | 1.470 | 0.769–2.810 | 0.244 | ||||||
| NI | |||||||||
| no | REF | ||||||||
| yes | 1.213 | 0.634–2.319 | 0.560 | ||||||
| TRG grade | |||||||||
| 0/1 | REF | REF | REF | ||||||
| 2//3 | 1.644 | 0.766–3.532 | 0.202 | 1.196 | 0.495–2.889 | 0.691 | 0.989 | 0.382–2.558 | 0.982 |
| Post-AC | |||||||||
| no | REF | ||||||||
| yes | 0.602 | 0.280–1.296 | 0.195 | ||||||
| Postoperation complication | |||||||||
| no | REF | REF | REF | ||||||
| yes | 2.491 | 1.177–5.273 | 0.017 | 2.061 | 0.902–4.711 | 0.086 | 2.055 | 0.906–4.664 | 0.085 |
| CA72-4-related Ia | |||||||||
| Pre-NACT CA72-4 | |||||||||
| < 3.7 | REF | REF | NA | NA | NA | ||||
| ≥ 3.7 | 2.126 | 1.116–4.053 | 0.022 | 1.408 | 0.686–2.889 | 0.351 | NA | NA | NA |
| Post-NACT CA72-4 | |||||||||
| < 3.7 | REF | REF | NA | NA | NA | ||||
| ≥ 3.7 | 2.482 | 1.298–4.744 | 0.006 | 1.843 | 0.848–4.007 | 0.123 | NA | NA | NA |
| CA72-4-related IIb | |||||||||
| Group-based trajectory of CA72-4, n(%) | |||||||||
| normal | REF | NA | NA | NA | REF | ||||
| elevated | 1.247 | 0.449–3.466 | 0.672 | NA | NA | NA | 1.543 | 0.528–4.513 | 0.428 |
| descend | 0.819 | 0.235–2.852 | 0.753 | NA | NA | NA | 0.751 | 0.201–2.809 | 0.670 |
| stable | 3.443 | 1.659–7.145 | 0.001 | NA | NA | NA | 3.442 | 1.574–7.528 | 0.002 |
1:HR = Hazard Ratio, CI = Confidence Interval
Bold values indicated that the P value < 0.05
a: model I: Including only pre-NACT CA72-4 and post-NACT CA72-4 levels
b: model II: Only the group-based of trajectory of CA72-4 levels was included
Abbreviation REF: Reference; ECOG score: Eastern Cooperative Oncology Group (ECOG) Performance Status score; ypT: Tumor (T pathological stage) after neoadjuvant chemotherapy; ypN: Nodes pathological stage after neoadjuvant chemotherapy; TRG: Tumor Regression Grade; NACT: Neoadjuvant chemotherapy; CA72-4: Carbohydrate antigen 72 − 4