Fig. 1.

F. nucleatum abundance in CRC tumors is correlated with poor survival and DNA damage A Spearman’s correlation of F. nucleatum relative abundance (RA) with mutation load (log10 number of non-synonymous mutation per sample) in TCGA colon adenocarcinomas (COAD). B Kaplan–Meier curves of patient’s overall survival from TCGA-COAD based on F. nucleatum load (determined by PathSeq analysis) and mutation load. P values were determined by the Log-rank Mantel-Cox text. High F. nucleatum load: F. nucleatum RA values (> 50 percentile); low F. nucleatum RA values (< 50 percentile). High mutation load: log10 number of non-synonymous mutation per sample > 2: low mutation load: log10 number of non-synonymous mutation per sample < 2. C High F. nucleatum RA-associated genes enriched in DNA damage-related pathways. D Differential gene expression in High- and Low F. nucleatum samples