Fig. 3.

F. nucleatum induces DNA damage in vivo. C57BL/6 mice were administered with antibiotics through drinking water for 2 weeks. Then mice were administered with 10⁸ CFU F. nucleatum or PBS 5 times per week for 30 weeks by gavage. A DNA of colon tissue was extracted and performed whole genome sequence. B Pipeline of whole genome sequencing analysis. C Comparison of the number of different structure variations between F. nucleatum samples and control samples. BND: break-end; DEL deletion, DUP Duplication, INS Insertion, INV Inversion. ***p ≤ 0.001; **p ≤ 0.01; *p < 0.05; NS, not significant; Wilcoxon rank-sum test