Table 3.
MR results between the CVH score and different measures of EAA in TWB
| Outcome | F | IV | β (SE) | 95% CI | p-value |
|---|---|---|---|---|---|
| HannumEAA | 21.9 | CVH-wGRS (14 SNPs) | − 0.442 (0.380) | (− 1.189, 0.301) | 0.2426 |
| IEAA | 21.9 | CVH-wGRS (14 SNPs) | − 0.206 (0.387) | (-0.965, 0.552) | 0.5938 |
| PhenoEAA | 21.9 | CVH-wGRS (14 SNPs) | − 0.163 (0.503) | (− 1.150, 0.824) | 0.7461 |
| GrimEAA | 21.6 | CVH-wGRS (14 SNPs) | − 0.993 (0.363) | (− 1.705, − 0.280) | 0.0063 |
| DNAmPAI-1 | 24.3 | CVH-wGRS (13 SNPs) | − 0.294 (0.099) | (− 0.488, − 0.100) | 0.0030 |
| DunedinPACE | 21.9 | CVH-wGRS (14 SNPs) | − 0.021 (0.011) | (− 0.043, 0.001) | 0.0637 |
IEAA: Horvath’s intrinsic epigenetic age acceleration; bold font indicates significant MR results (p-value < 0.05)