Table 4.
MR results between CVH metrics and different EAA in TWB
| IV | F | β (SE) | 95%CI | p-value | q-value | |
|---|---|---|---|---|---|---|
| HannumEAA | ||||||
| TC score | TC-wGRS (74 SNPs) | 122.6 | 0.122 (0.510) | (− 0.879, 1.122) | 0.8118 | 0.8655 |
| FG score | FG-wGRS (33 SNPs) | 43.7 | 0.180 (1.065) | (− 1.908, 2.269) | 0.8655 | 0.8655 |
| BP score | BP-wGRS (31 SNPs) | 15.5 | 0.254 (1.273) | (− 2.252, 2.743) | 0.8417 | 0.8655 |
| BMI score | BMI-wGRS (28 SNPs) | 18.6 | − 2.541 (1.069) | (− 4.636, -0.446) | 0.0175 | 0.0698 |
| IEAA | ||||||
| TC score | TC-wGRS (74 SNPs) | 121.3 | − 0.178 (0.518) | (− 1.193, 0.838) | 0.7319 | 0.9759 |
| FG score | FG-wGRS (33 SNPs) | 44.1 | 0.605 (1.077) | (− 1.507, 2.717) | 0.5743 | 0.9759 |
| BP score | BP-wGRS (31 SNPs) | 15.1 | − 0.011 (1.316) | (− 2.594, 2.569) | 0.9936 | 0.9936 |
| BMI score | BMI-wGRS (32 SNPs) | 21.2 | − 1.014 (1.014) | (− 3.002, 0.973) | 0.3171 | 0.9759 |
| PhenoEAA | ||||||
| TC score | TC-wGRS (74 SNPs) | 121.3 | 0.392 (0.677) | (− 0.936, 1.719) | 0.5631 | 0.8429 |
| FG score | FG-wGRS (33 SNPs) | 43.9 | − 0.275 (1.389) | (− 3.000, 2.449) | 0.8429 | 0.8429 |
| BP score | BP-wGRS (31 SNPs) | 15.3 | − 0.400 (1.703) | (− 3.742, 2.938) | 0.8141 | 0.8429 |
| BMI score | BMI-wGRS (32 SNPs) | 21.3 | − 2.729 (1.322) | (− 5.323, -0.136) | 0.0392 | 0.1566 |
| GrimEAA | ||||||
| TC score | TC-wGRS (74 SNPs) | 121.1 | − 0.313 (0.482) | (− 1.258, 0.632) | 0.5163 | 0.6884 |
| FG score | FG-wGRS (33 SNPs) | 44.0 | − 0.721 (1.014) | (− 2.708, 1.267) | 0.4771 | 0.6884 |
| BP score | BP-wGRS (31 SNPs) | 15.5 | 0.331 (1.230) | (− 2.084, 2.739) | 0.7876 | 0.7876 |
| BMI score | BMI-wGRS (32 SNPs) | 21.2 | − 2.382 (0.952) | (− 4.250, -0.514) | 0.0125 | 0.0498 |
| DNAmPAI-1 (a DNAm-based surrogate plasma protein of GrimAge) | ||||||
| TC score | TC-wGRS (68 SNPs) | 104.6 | − 0.452 (0.150) | (− 0.745, -0.158) | 0.0026 | 0.0102 |
| FG score | FG-wGRS (32 SNPs) | 41.2 | − 0.123 (0.306) | (-0.723, 0.477) | 0.6878 | 0.6878 |
| BP score | BP-wGRS (31 SNPs) | 15.1 | 0.186 (0.358) | (− 0.520, 0.885) | 0.6102 | 0.6878 |
| BMI score | BMI-wGRS (32 SNPs) | 21.2 | − 0.470 (0.279) | (− 1.016, -0.076) | 0.0920 | 0.1840 |
| DunedinPACE | ||||||
| TC score | TC-wGRS (74 SNPs) | 121.7 | 0.005 (0.015) | (− 0.244, 0.034) | 0.7368 | 0.7368 |
| FG score | FG-wGRS (33 SNPs) | 43.5 | − 0.013 (0.031) | (− 0.074, 0.048) | 0.6792 | 0.7368 |
| BP score | BP-wGRS (31 SNPs) | 15.3 | 0.031 (0.038) | (− 0.044, 0.106) | 0.4229 | 0.7368 |
| BMI score | BMI-wGRS (32 SNPs) | 20.9 | − 0.097 (0.030) | (− 0.154, -0.039) | 0.0011 | 0.0044 |
TC score: ideal total cholesterol score; FG score: ideal fasting glucose score; BP score: ideal blood pressure score; BMI score: ideal body mass index score; Bold font indicates that the MR results are significant after the FDR correction (q < 0.05)