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. 2024 Jun 24;20(4):1153–1163. doi: 10.4103/NRR.NRR-D-23-01397

Figure 2.

Figure 2

MSC-EVs attenuate the activation of hippocampal NLRP3 inflammasome complex induced by binge-like ethanol treatment in adolescent mice.

(A) The mRNA expression of components of the NLRP3 inflammasome complex, such as NLRP3, CASP-1, and ASC in the hippocampus. (B) The mRNA expression of the proinflammatory IL-1β and IL-18. Data are presented as mean ± SEM, n = 8 mice/group. *P < 0.05, **P < 0.01, ***P < 0.001, vs. saline-treated group; #P < 0.05, ##P < 0.01, ###P < 0.001, vs. ethanol-treated group; $$$P < 0.001, vs. saline + MSC-EVs treated group (one-way analysis of variance with Bonferroni’s post hoc test). ASC: Apoptosis-associated speck-like protein containing a CARD; CASP-1: caspase-1; EVs: extracellular vesicles; IL: interleukin; mRNA: messenger ribonucleic acid; MSC-EVs: mesenchymal stem cell-derived EVs; NLRP3: NOD-, LRR- and pyrin domain-containing protein 3.