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. 2024 Jun 24;20(4):1153–1163. doi: 10.4103/NRR.NRR-D-23-01397

Figure 4.

Figure 4

MSC-EVs diminish the activation of other NLR-related genes induced by binge-like ethanol treatment in adolescent mice.

(A) The mRNA expression of CASP11/4, TLR4, and IRAK1 in the hippocampus. (B) The mRNA expression of NLRP1, AIM2 and NLRC4. Data are presented as mean±SEM, n = 8 mice/group. *P < 0.05, **P < 0.01, ***P < 0.001, vs. saline-treated group; #P < 0.05, ##P < 0.01, ###P < 0.001, vs. ethanol-treated group (one-way analysis of variance with Bonferroni’s post hoc test). AIM2: Absent in melanoma 2; CASP11/4: caspase-11/14; EVs: extracellular vesicles; IL: interleukin; IRAK: interleukin 1 receptor associated kinase 1; MSC-EVs: mesenchymal stem cell-derived EVs; NLRP1: pyrin domain-containing 1; NLRC4: caspase recruitment domain-containing 4; NLRP3: NOD-, LRR- and pyrin domain-containing protein 3; NLRs: nucleotide-binding oligomerization domain-like receptors; TLR4: toll-like receptor 4.