Table 2.
Colistin PK/PD profile and CRTT settings
| Colistin PK/PD parameters | |
|---|---|
| Cmax, mcg/mL | 16.65 [14.77–20.64] |
| Cmin, mcg/mL | 3.93 [3.29–4.37] |
| Css, avg, mcg/mL | 8.07 [7.1–8.69] |
| t1/2, h | 20.89 [14.45–22.84] |
| Vd, L | 126.37 [79.57-139.17] |
| CLTOT, L/h | 2.08 [1.94–2.37] |
| CLCRRT, L/h | 1.21 [0.88–1.35] |
| %CLTOT, L/h | 49.2 [39.25–64.2] |
| %E | 17.65 [14.98–21.67] |
| AUC0 − 24, mcg h/mL | 193.86 [170.6–208.65] |
| fAUC0 − 24, mcg h/mL | 58.16 [51.18–62.6] |
| fAUC0 − 24/0.5 mcg/mL ≥ 12 | 20 (1) |
| fAUC0 − 24/1 mcg/mL ≥ 12 | 20 (1) |
| fAUC0 − 24/2 mcg/mL ≥ 12 | 20 (1) |
| fAUC0 − 24/4 mcg/mL ≥ 12 | 17 (85) |
| fAUC0 − 24/6 mcg/mL ≥ 12 | 1 (5) |
Categorical variables are expressed as count (percentage); continuous variables are expressed as median [interquartile range]
*Measure on the sampling day
Abbreviations: CMS: colistimethate; Cssavg: average steady-state concentration;. Cmax: maximum concentration; Cmin: minimum concentration; AUC: Area Under The Curve; Vd: distribution volume; t1/2: half-life; CL: clearance; %E: % filter extraction