Table 1.
Cancer type
|
Eph receptor
|
Aberrant function
|
Role of Eph receptor
|
Colorectal cancer | EphA1 | Overexpressed in early stages; low expression in later stages | Tumour suppressive |
EphA2 | Overexpressed in early stages; low expression in later stages | Tumour suppressive | |
EphA3 | Low expression | Tumour suppressive | |
EphA4 | Overexpressed | Tumour promoting | |
EphA7 | Low expression | Tumour suppressive | |
EphB2 | Overexpressed in early stages; low expression in later stages | Tumour suppressive | |
EphB3 | Overexpressed in early stages; low expression in later stages | Tumour suppressive | |
EphB4 | Overexpressed | Tumour promoting | |
EphB6 | Low expression | Tumour suppressive |
Eph: Erythropoietin-induced hepatocyte.