Table 1.

Studies assessing plasma donor-derived cell-free DNA for the diagnosis of rejection using commercially available assays

Ref.	Assay used	Patient number	Threshold (%)	Sen/Spec	PPV/NPV
Bloom et al[3]	AlloSure	102	1	59/85	61/84
Sigdel et al[5]	Prospera	193	1	88.7/72.6	52/95
Huang et al[17]	AlloSure	63	0.74	79/72	77/75
Bu et al[7]	AlloSure	1092	0.5	78/71	50/90
Bromberg et al[8]	Prospera	424	1	79/85.3	32.6/97.9

Sen: Sensitivity; Spec: Specificity; PPV: Positive predictive value; NPV: Negative predictive value.