Fig. 7. The influence of ASPP1 on cardiac fibrosis.

ASPP1 was up-regulated during cardiac fibrosis after MI, which bound more OTUB1 and thus inhibited OTUB1 interaction with p53. The deubiquitination of p53 was therefore decreased resulting in its enhanced ubiquitination and degradation. The degradation of p53 accelerated the cell cycle progression of fibroblasts and promoted cardiac fibrosis. Ub, ubiquitin. The diagram was created using Figdraw.