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Physicochemical properties of the selected compounds (6e, 6f)
| Compound | TPSA | RBC | Log P | HBD | HBA | MW |
|---|---|---|---|---|---|---|
| 6e | 85.34 | 4 | 3.64 | 1 | 4 | 414.50 |
| 6f | 109.13 | 4 | 3.45 | 1 | 5 | 425.48 |
Abbreviations: MW, molecular weight; HBA, number of H-bond acceptors; HBD, number of H-bond donors; Log P, the octanol-water partition coefficient; RBC, rotatable bond count; TPSA, topological polar surface area
