Fig. 1. The schemes of experimental applications in the study groups. The animals were divided equally into six groups of Control, Cisplatin, AP39, Cisplatin + AP39, CIS, and CIS + AP39 (n = 10). The experiments were completed in 55 days in the CIS POF model groups and 25 days in the cisplatin POF model groups. The rats were kept in the immobilization apparatus for 1 hour during the initial 19 days, 2 hours during the next 18 days, and 3 hours during the remaining 18 days. AP39 was administered ip. on the 11–55th days or 11–25th days depending on the AP39 treatment groups. CIS: chronic immobilization stress, POF: premature ovarian failure.