Table 1.
Mendelian randomization analyses of the causal effects between gut microbiota and lymphocytic leukemia.
| Outcome | Exposure | N SNP |
Q statistic | P heterogeneity |
P intercept |
Steiger pval |
|---|---|---|---|---|---|---|
| Lymphoid leukemia | family.Lachnospiraceae.id.1987 | 16 | 21.473 | 0.122 | 0.606 | 0.574 |
| family.Lactobacillaceae.id.1836 | 8 | 3.797 | 0.803 | 0.775 | 0.429 | |
| genus.Allisonella | 8 | 7.670 | 0.363 | 0.607 | 0.245 | |
| genus.Anaerotruncus | 13 | 7.405 | 0.830 | 0.965 | 0.573 | |
| genus.Eubacteriumbrachygroup | 10 | 10.928 | 0.281 | 0.063 | 0.306 | |
| genus.Lactococcus | 8 | 6.221 | 0.514 | 0.588 | 0.270 | |
| genus.RuminococcaceaeNK4A214group | 13 | 9.275 | 0.679 | 0.884 | 0.535 | |
| genus.unknowngenus.id.2071 | 15 | 11.490 | 0.647 | 0.941 | 0.462 | |
| genus.unknowngenus.id.959 | 11 | 7.810 | 0.647 | 0.638 | 0.263 | |
| genus.Victivallis | 10 | 8.684 | 0.467 | 0.563 | 0.199 | |
| family.Micrococcaceae | 5 | 1.215 | 0.876 | 0.807 | 0.612 | |
| family.Clostridiales_noname | 6 | 3.978 | 0.553 | 0.923 | 0.621 | |
| genus.Rothia | 5 | 1.222 | 0.874 | 0.812 | 0.566 | |
| genus.Escherichia | 8 | 5.078 | 0.651 | 0.845 | 0.535 | |
| genus.Eubacterium | 9 | 5.099 | 0.747 | 0.392 | 0.496 | |
| genus.Bacteroides | 15 | 10.315 | 0.739 | 0.440 | 0.416 | |
| genus.Coprococcus | 4 | 1.668 | 0.644 | 0.482 | 0.701 | |
| ALL | class.Mollicutes.id.3920 | 12 | 9.120 | 0.611 | 0.962 | 0.531 |
| family.FamilyXI.id.1936 | 8 | 6.143 | 0.523 | 0.275 | 0.228 | |
| family.Lachnospiraceae.id.1987 | 16 | 10.963 | 0.755 | 0.116 | 0.569 | |
| family.Pasteurellaceae.id.3689 | 13 | 8.285 | 0.762 | 0.091 | 0.413 | |
| genus.Dorea.id.1997 | 10 | 15.094 | 0.088 | 0.204 | 0.640 | |
| genus.Eubacteriumfissicatenagroup.id.14373 | 9 | 11.347 | 0.183 | 0.668 | 0.327 | |
| genus.Gordonibacter.id.821 | 11 | 11.316 | 0.333 | 0.132 | 0.197 | |
| genus.Oscillibacter.id.2063 | 13 | 14.524 | 0.268 | 0.554 | 0.394 | |
| order.Pasteurellales.id.3688 | 13 | 8.285 | 0.762 | 0.091 | 0.413 | |
| phylum.Tenericutes.id.3919 | 12 | 9.120 | 0.611 | 0.962 | 0.531 | |
| genus.Roseburia | 11 | 11.616 | 0.312 | 0.718 | 0.442 | |
| genus.Barnesiella | 13 | 7.077 | 0.852 | 0.264 | 0.457 | |
| genus.Eubacterium | 10 | 5.194 | 0.817 | 0.590 | 0.495 | |
| genus.Roseburia | 11 | 7.117 | 0.714 | 0.419 | 0.455 | |
| CLL | genus.Eggerthella | 9 | 9.177 | 0.328 | 0.614 | 0.395 |
| genus.Eubacteriumbrachygroup | 10 | 9.249 | 0.415 | 0.165 | 0.306 | |
| genus.Howardella | 9 | 4.291 | 0.830 | 0.281 | 0.296 | |
| genus.Lactococcus | 8 | 4.730 | 0.693 | 0.348 | 0.269 | |
| genus.RuminococcaceaeUCG005 | 14 | 14.568 | 0.335 | 0.866 | 0.552 | |
| class.Erysipelotrichia | 7 | 6.199 | 0.401 | 0.159 | 0.581 | |
| family.Erysipelotrichaceae | 7 | 6.198 | 0.401 | 0.159 | 0.581 | |
| order.Erysipelotrichales | 7 | 6.199 | 0.401 | 0.159 | 0.581 | |
| genus.Coprococcus | 4 | 2.354 | 0.502 | 0.461 | 0.701 |
NSNP refers to the number of SNPs used for analysis; the Q statistic is a statistical measure of heterogeneity, with a higher value indicating a more significant difference between study results.