Table 3.
Mendelian randomization analyses of the causal effects between immune cells and Lymphoid leukaemia.
| Outcome | Exposure | N snp |
Q statistic | P heterogeneity |
P intercept |
Steiger pval |
|---|---|---|---|---|---|---|
| Lymphoid leukaemia | CD62L- plasmacytoid Dendritic Cell %Dendritic Cell | 3 | 0.560 | 0.756 | 0.591 | 0.003 |
| Secreting CD4 regulatory T cell %CD4 regulatory T cell | 5 | 2.831 | 0.587 | 0.333 | 9.98E-05 | |
| Activated & resting CD4 regulatory T cell %CD4 regulatory T cell | 5 | 2.864 | 0.581 | 0.328 | 8.77E-05 | |
| Monocytic Myeloid-Derived Suppressor Cells Absolute Count | 5 | 4.375 | 0.358 | 0.201 | 1.44E-05 | |
| Basophil %CD33dim HLA DR- CD66b- | 3 | 1.169 | 0.557 | 0.548 | 3.02E-05 | |
| HLA DR+ T cell Absolute Count | 3 | 0.401 | 0.818 | 0.714 | 6.52E-05 | |
| HLA DR+ T cell%T cell | 4 | 1.703 | 0.636 | 0.646 | 4.93E-07 | |
| HLA DR+ CD8+ T cell Absolute Count | 3 | 0.412 | 0.814 | 0.691 | 0.0002 | |
| HLA DR+ CD8+ T cell %T cell | 3 | 0.474 | 0.789 | 0.711 | 8.15E-06 | |
| CD45RA- CD28- CD8+ T cell %T cell | 35 | 35.780 | 0.385 | 0.261 | 6.31E-06 | |
| IgD on IgD+ CD24- B cell | 5 | 3.732 | 0.444 | 0.786 | 3.23E-13 | |
| IgD on IgD+ CD38dim B cell | 5 | 3.678 | 0.451 | 0.831 | 1.35E-10 | |
| CD16-CD56 on Natural Killer | 7 | 8.651 | 0.194 | 0.768 | 1.47E-31 | |
| CD33 on CD14+ monocyte | 6 | 3.364 | 0.644 | 0.472 | 4.58E-72 | |
| CD33 on CD33+ HLA DR+ CD14dim | 4 | 1.181 | 0.757 | 0.673 | 8.49E-69 | |
| CD33 on CD33dim HLA DR+ CD11b+ | 7 | 3.493 | 0.745 | 0.413 | 3.90E-73 | |
| CD33 on CD33dim HLA DR+ CD11b- | 6 | 1.938 | 0.858 | 0.484 | 3.11E-68 | |
| CD33 on Granulocytic Myeloid-Derived Suppressor Cells | 3 | 1.078 | 0.583 | 0.600 | 7.74E-12 | |
| CD33 on CD66b++ myeloid cell | 5 | 1.304 | 0.861 | 0.590 | 4.85E-30 | |
| CD33 on Monocytic Myeloid-Derived Suppressor Cells | 3 | 0.481 | 0.786 | 0.761 | 1.08E-50 | |
| CD33 on CD33dim HLA DR- | 6 | 4.425 | 0.490 | 0.963 | 2.83E-47 | |
| CD33 on basophil | 7 | 6.477 | 0.372 | 0.762 | 6.46E-51 | |
| CD33 on Immature Myeloid-Derived Suppressor Cells | 6 | 6.067 | 0.300 | 0.658 | 2.72E-46 | |
| CD33 on CD33+ HLA DR+ | 4 | 1.193 | 0.755 | 0.664 | 5.41E-71 | |
| CD33 on CD33+ HLA DR+ CD14- | 4 | 1.181 | 0.758 | 0.661 | 4.70E-72 | |
| FSC-A on plasmacytoid Dendritic Cell | 4 | 2.789 | 0.425 | 0.428 | 0.160 | |
| HLA DR on monocyte | 5 | 3.342 | 0.502 | 0.545 | 2.51E-12 | |
| SSC-A on plasmacytoid Dendritic Cell | 4 | 2.775 | 0.428 | 0.369 | 0.116 | |
| HLA DR on B cell | 9 | 7.519 | 0.482 | 0.748 | 9.72E-15 | |
| CD45RA+ CD28- CD8+ T cell Absolute Count | 16 | 21.243 | 0.129 | 0.811 | 0.009 | |
| ALL | CD62L- plasmacytoid Dendritic Cell %Dendritic Cell | 3 | 0.994 | 0.608 | 0.962 | 0.003 |
| CD28+ CD45RA+ CD8dim T cell Absolute Count | 8 | 6.900 | 0.439 | 0.542 | 0.015 | |
| CD45RA+ CD28- CD8+ T cell %T cell | 60 | 46.960 | 0.871 | 0.163 | 8.93E-10 | |
| CD38 on IgD+ CD38+ B cell | 3 | 2.463 | 0.292 | 0.361 | 0.149 | |
| CD38 on IgD+ CD38dim B cell | 4 | 1.398 | 0.706 | 0.777 | 0.009 | |
| CD38 on IgD- CD38dim B cell | 3 | 0.367 | 0.833 | 0.763 | 0.032 | |
| CD38 on naive-mature B cell | 3 | 0.431 | 0.806 | 0.800 | 0.076 | |
| CD38 on transitional B cell | 5 | 2.556 | 0.635 | 0.424 | 0.007 | |
| CD3 on Effector Memory CD8+ T cell | 3 | 1.014 | 0.602 | 0.876 | 0.005 | |
| FSC-A on Natural Killer | 3 | 2.115 | 0.347 | 0.448 | 0.070 | |
| HLA DR on CD14- CD16+ monocyte | 5 | 2.173 | 0.704 | 0.528 | 1.36E-07 | |
| CD80 on granulocyte | 3 | 1.130 | 0.568 | 0.519 | 0.096 | |
| CLL | Switched memory B cell %lymphocyte | 3 | 2.369 | 0.306 | 0.395 | 0.314 |
| HLA DR+ T cell Absolute Count | 3 | 1.107 | 0.575 | 0.486 | 6.54E-05 | |
| HLA DR+ T cell%T cell | 4 | 3.371 | 0.338 | 0.505 | 4.98E-07 | |
| HLA DR+ CD8+ T cell Absolute Count | 3 | 1.287 | 0.525 | 0.462 | 0.0002 | |
| HLA DR+ CD8+ T cell %T cell | 3 | 0.349 | 0.840 | 0.674 | 8.14E-06 | |
| CD45RA- CD28- CD8+ T cell %CD8+ T cell | 10 | 11.319 | 0.254 | 0.561 | 0.009 | |
| BAFF-R on IgD+ CD38- naive B cell | 7 | 2.600 | 0.857 | 0.507 | 2.27E-63 | |
| CD25 on IgD+ CD38+ B cell | 3 | 1.765 | 0.414 | 0.613 | 0.087 | |
| IgD on IgD+ CD38+ B cell | 4 | 0.696 | 0.874 | 0.581 | 9.25E-17 | |
| IgD on transitional B cell | 4 | 3.072 | 0.381 | 0.672 | 3.56E-08 | |
| CD16-CD56 on Natural Killer | 7 | 9.097 | 0.168 | 0.387 | 1.48E-31 | |
| FSC-A on plasmacytoid Dendritic Cell | 4 | 2.359 | 0.501 | 0.270 | 0.160 | |
| SSC-A on plasmacytoid Dendritic Cell | 4 | 0.784 | 0.853 | 0.713 | 0.116 |
NSNP refers to the number of SNPs used for analysis; the Q statistic is a statistical measure of heterogeneity, with a higher value indicating a more significant difference between study results.