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. 2024 Sep 16;15:1458967. doi: 10.3389/fimmu.2024.1458967

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Copyright © 2024 Govaerts, Van Breedam, De Beuckeleer, Goethals, D’Incal, Di Stefano, Van Calster, Buyle-Huybrecht, Boeren, De Reu, Paludan, Thiry, Lebrun, Sadzot-Delvaux, Motaln, Rogelj, Van Weyenbergh, De Vos, Vanden Berghe, Ogunjimi, Delputte and Ponsaerts

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VZV^eGFP-ORF23 and SeV^eGFP-infected NSPHs display opposite effects on protein expression related to Type-I interferon response and antigen presentation pathway. Representative immunofluorescence images for 5-month-old control NSPHs (CTRL, n=6), NSPHs inoculated with eGFP+ control ARPE19 cells (ARPE-CTRL, green, n=6), NSPHs inoculated with VZV^eGFP-ORF23-infected ARPE19 cells (VZV^eGFP-ORF23, green, n=6), and NSPHs infected with SeV^eGFP (SeV^eGFP, green, n=6), immunolabelled for (A) Type-I interferon response markers MX1, IFIT2 and ISG15, and (B) antigen presentation pathway markers HLA-DR and CD74. All in magenta. Nuclei are labelled with DAPI (blue). Scale bars of 100 µm are indicated on the images. Combined box/dotplots showing signal quantification. The mean value for each individual NSPH analysed is given as a dot within the boxplot. * p<0,05. ** p<0,01. *** p<0,001. **** p<0,0001.