Table 1. The study cohort stratified by TTh at TTh (TU).
| TTh-treated | TTh-untreated | |
|---|---|---|
| Patients (n) | 353 | 384 |
| Age (y) | 60.0/55.0–64.0/33.0–71.0 | 64.0/60.0–67.0/45.0–74.0 |
| Follow-up (mo) | 105.0/78.0–141.0/24.0–153.0 | 114.0/96.0–126.0/24.0–156.0 |
| Baseline systolic BP (mmHg) | 158.0/141.0–167.0/121.0–189.0 | 137.5/131.5–154.0/115.0–193.0 |
| Final systolic BP (mmHg) | 128.0/123.5–133.5/120.0–154.0 (n=352) | 149.0/142.0–159.0/131.0–215.0 (n=382) |
| Change in systolic BP (mmHg) | -25.0/-59.0 to -13.0/-63.0 to 3.0 (n=352) | 10.0/-11.0 to 16.0/-18.0 to 82.0 (n=382) |
| Final vs. baseline systolic BP: p (sign-rank test) | p<0.0001 | p<0.0001 |
| Baseline diastolic BP (mmHg) | 94.0/83.0–98.0/69.0–126.0 | 78.0/75.0–88.0/66.0–121.0 |
| Final diastolic BP (mmHg) | 75.0/73.0–78.0/68.0–94.0 (n=352) | 89.0/83.0–96.0/71.0–148.0 (n=381) |
| Change in diastolic BP (mmHg) | -17.0/-24.0 to -9.0/-45.0 to +7.0 (n=352) | 8.0/3.9–13.0/-14.0 to 68.0 (n=381) |
| Final vs. baseline diastolic BP: p (sign-rank test) | p<0.0001 | p<0.0001 |
| Baseline pulse pressure (mmHg) | 62.0/58.0–68.0/38.0–90.0 | 59.0/57.0–64.0/37.0–93.0 |
| Final pulse pressure (mmHg) | 52.0/49.0–58.0/35.0–97.0 (n=352) | 59.0/58.0–67.0/49-0–99.0 (n=381) |
| Change in pulse pressure (mmHg) | -8.0/-15.0 to -4.0/-34.0 to 44.0(n=352) | 1.0/-2.0 to 5.0/-17.0 to 53.0 (n=381) |
| Final vs. baseline pulse pressure: p (sign-rank test) | p<0.0001 | p<0.0001 |
| Baseline WC (cm) | 108.0/100.0–114.0/86.0–166.0 | 109.0/102.5–116.0/93.0–155.0 |
| Final WC (cm) | 97.0/94.0–101.0/78.0–157.0 | 113.0/108.0–121.0/95.0–165.0 |
| Final vs. baseline WC | p<0.0001 | p<0.0001 |
| Baseline HCT | 44.0/43.0–46.0/330–50.0 | 46.0/45.0–47.0/43.0–50.0 |
| Final HCT | 49.0/48.0–50.0/46.0–52.0 | 46.0/45.0–47.0/33.0–53.0 |
| Final vs. baseline HCT: p (sign-rank test) | p<0.0001 | p=0.014 |
Values are presented as median/IQR/range.
Details (median [IQR]) of systolic BP, diastolic BP, and pulse pressure in subgroups stratified by antihypertensive treatment at baseline.
a. TTh-treated (1. Not on antihypertensives at baseline, 2. On antihypertensives at baseline)
1. Men not on antihypertensives at baseline (n=152)
Baseline BP values (systolic BP=139 [133.5, 145.5] mmHg, diastolic BP=82 [78, 88] mmHg, pulse pressure=59.0 [54.5–61.0] mmHg).
Change from baseline (systolic BP=-12 [-19, -8] mmHg [p<0.0001], diastolic BP=-8 [-13.5, -3] mmHg [p<0.0001], pulse pressure=-6 [-10, -1] mmHg [p<0.0001]).
2. Men on antihypertensives at baseline (n=201)
Baseline BP values (systolic BP=166 [159, 174] mmHg, diastolic BP=98 [95, 104] mmHg, pulse pressure=67 [62, 70] mmHg).
Change from baseline (systolic BP=-35 [-43, -27] mmHg [p<0.0001], diastolic BP=-22 [-28, -18] mmHg [p<0.0001], pulse pressure=-11 [-17, -6] mmHg [p<0.0001]).
b. TTh-untreated (1. Not on antihypertensives at baseline, 2. On antihypertensives at baseline)
1. Men not on antihypertensives at baseline (n=248)
Baseline BP values (systolic BP=132 [129, 137] mmHg, diastolic BP=76 [73.5, 78.5] mmHg, pulse pressure=58 [54, 60] mmHg).
Change from baseline (systolic BP=11 [7, 18] mmHg [p<0.0001], diastolic BP=9 [5, 15] mmHg [p<0.0001], pulse pressure=2 [-1, 6] mmHg [p<0.0001]).
2. Men on antihypertensives at baseline (n=136)
Baseline BP values (systolic BP=155 [153, 160] mmHg, diastolic BP=91 [86, 95] mmHg, pulse pressure=67 [61, 69] mmHg).
Change from baseline (systolic BP=6 [0, 12] mmHg [p<0.0001], diastolic BP=6 [2, 11] mmHg [p<0.0001], pulse pressure=0 [-2, 4] mmHg [p=0.24]).
TTh: testosterone therapy, TU: testosterone undecanoate, BP: blood pressure, WC: waist circumference, HCT: hematocrit, IQR: interquartile range.