Table 3. Factors associated with change in systolic, diastolic, and pulse pressure in TTh-treated men never on antihypertensive agents.
| TTh-treated men not on antihypertensive agents | Multiple regression analyses: (95% CI), p-value | |||
|---|---|---|---|---|
| Association with WC | Association with HCT | Association with WC and HCT | ||
| Outcome: Change in systolic BP | ||||
| Age (y) | 0.092 (-0.020 to 0.20), 0.11 | 0.098 (-0.0086 to 0.20), 0.071 | 0.079 (-0.033 to 0.19), 0.16 | |
| Baseline systolic BP (mmHg) | -0.93 (-1.01 to -0.85), <0.001 | -0.92 (-1.00 to -0.84), <0.001 | -0.94 (-1.02 to -0.86), <0.001 | |
| Follow-up (mo) | 0.019 (-0.0087 to 0.047), 0.18 | 0.016 (-0.0086 to 0.041), 0.20 | 0.0053 (-0.025 to 0.035), 0.73 | |
| Change in WC (cm) | -0.16 (-0.47 to 0.16), 0.33 | -0.18 (-0.49 to 0.14), 0.27 | ||
| Baseline WC (cm) | -0.067 (-0.27 to 0.13), 0.51 | -0.026 (-0.23 to 0.18), 0.80 | ||
| Change in HCT | 0.084 (-0.46 to 0.63), 0.76 | 0.029 (-0.52 to 0.58), 0.92 | ||
| Baseline HCT | -0.17 (-0.74 to 0.41), 0.56 | -0.30 (-0.90 to 0.31), 0.34 | ||
| Outcome: Change in diastolic BP | ||||
| Age (y) | -0.027 (-0.16 to 0.11), 0.69 | -0.0092 (-0.14 to 0.12), 0.87 | -0.025 (-0.16 to 0.11), 0.71 | |
| Baseline Diastolic BP (mmHg) | -0.92 (-1.06 to -0.77), <0.001 | -0.91 (-1.06 to -0.77), <0.001 | -0.92 (-1.07 to 0.78), <0.001 | |
| Follow-up (mo) | 0.015 (-0.022 to 0.052), 0.42 | 0.021 (-0.011 to 0.054), 0.20 | 0.017 (-0.023 to 0.056), 0.41 | |
| Change in WC (cm) | -0.059 (-0.42 to 0.31), 0.75 | -0.060 (-0.42 to 0.30), 0.75 | ||
| Baseline WC (cm) | 0.0091 (-0.23 to 0.25), 0.94 | 0.021 (-0.22 to 0.26), 0.86 | ||
| Change in HCT | -0.35 (-1.00 to 0.29), 0.28 | -0.39 (-1.05 to 0.27), 0.24 | ||
| Baseline HCT | -0.29 (-0.97 to 0.40), 0.41 | -0.38 (-1.10 to 0.35), 0.30 | ||
| Outcome: Change in pulse pressure | ||||
| Age (y) | 0.11 (-0.044 to 0.27), 0.16 | 0.10 (-0.048 to 0.25), 0.19 | 0.099 (-0.058 to 0.26), 0.21 | |
| Baseline pulse pressure (mmHg) | -0.90 (-1.07 to -0.74), <0.001 | -0.90 (-1.05 to -0.74), <0.001 | -0.91 (-1.07 to -0.74), <0.001 | |
| Follow-up (mo) | 0.00024 (-0.038 to 0.038), 0.99 | -0.0067 (-0.038 to 0.025), 0.68 | -0.014 (-0.056 to 0.028), 0.50 | |
| Change in WC (cm) | -0.11 (-0.57 to 0.34), 0.61 | -0.13 (-0.59 to 0.32), 0.57 | ||
| Baseline WC (cm) | -0.10 (-0.39 to 0.19), 0.49 | -0.068 (-0.36 to 0.22), 0.64 | ||
| Change in HCT | 0.42 (-0.34 to 1.19), 0.28 | 0.42 (-0.36 to 1.19), 0.29 | ||
| Baseline HCT | 0.096 (-0.71 to 0.90), 0.81 | 0.083 (-0.77 to 0.94), 0.85 | ||
TTh: testosterone therapy, CI: confidence interval, BP: blood pressure, WC: waist circumference, HCT: haematocrit.