Table 2.
Microcirculatory characteristics and inflammatory biomarkers in children with local vs. remote sepsis on PICU admission.
| Microcirculation evaluation variables | Total n = 178 | Local sepsis n = 61 | Remote sepsis n = 117 | P value1 |
|---|---|---|---|---|
| PBR, µm (SD) | 2.11 (0.28) | 2.08 (0.28) | 2.11 (0.29) | 0.37 |
| PBR flow corrected µm (IQR) | 2.06 (1.79–2.38) | 2.14 (1.89–2.25) | 2.03 (1.76–2.37) | 0.41 |
| Worst PBR, µm (IQR) | 3.24 (2.95–3.73) | 3.21 (2.96–3.76) | 3.26 (2.92–3.62) | 0.82 |
| 4–6 μm capillary density (IQR) | 24.95 (15.8-42.91) | 27.72 (18.9–41.3) | 23.51 (15.2-50.32) | 0.64 |
| Absolute capillary blood volume (IQR) | 5.9 (4.1–9.4) | 5.3 (4.4–8.6) | 6.1 (4.1–10.7) | 0.57 |
| Angiopoietin-2 ng/mL (IQR) | 11.1 (7.4–24.5) | 23.3 (10.3–24.7) | 10.6 (7.1–23.6) | 0.31 |
| CO2 delta (IQR) | 5.14 (3.21–7.05) | 5.06 (2.41–7.14) | 5.12 (3.22–7.15) | 0.69 |
| Ferritin, mg/dL (IQR) | 439.64 (185.08-1772.31) | 313.38 (159.17-557.17) | 514.21 (222.41–2280) | < 0.001 |
| Procalcitonin, g/dL (IQR) | 1.50 (0.41–6.28) | 1.09 (0.28–2.95) | 1.89 (0.53–7.46) | < 0.001 |
| D-dimer, mg/L (IQR) | 3.26 (1.21–7.52) | 1.63 (0.88–3.4) | 3.58 (2.34–9.91) | < 0.001 |
| Capillary refill time in seconds (IQR) | 1.43 (1.1–2.14) | 1.31 (0.82–172) | 1.51 (1.11–2.15) | 0.01 |
1Statistically significant p values are in bold (p < 0.05). P-values from the Student’s t test, Chi-square test, or Mann–Whitney U test, as applicable. PBR: perfused boundary region. CO2 delta: CO2 gap. IQR: interquartile range.