Table 8.
Pharmacokinetic parameters after oral administration of simvastatin-loaded SNEDDS and simvastatin suspension (equivalent to 40 mg/kg of simvastatin) to rats; data are expressed as the mean value (n = 3).
| Pharmacokinetic parameters | Drug suspension | SNEDDS (CL 14) | SNEDDS (EO5) |
|---|---|---|---|
| Ke (1/h) | 0.05 ± 0.01 | 0.06 ± 0.003* | 0.05 ± 0.006 |
| t½(h) | 14.52 ± 2.96 | 11.16 ± 0.58* | 13.05 ± 1.33 |
| Tmax (h) | 2 | 1 | 1 |
| Cmax (µg/mL) | 0.5568 ± 0.1545 | 1.02 ± 0.1288* | 1.235 ± 0.065** |
| AUC0-24 (µg/ml*h) | 4.532 ± 0.584 | 7.7349 ± 0.518** | 9.5314 ± 0.543** |
| AUC0-∞ (µg/ml*h) | 6.533 ± 0.176 | 9.865 ± 0.905** | 12.7239 ± 0.384** |
| AUMC0-∞ (µg/ml*h2) | 130.366 ± 24.375 | 150.607 ± 22.89 | 215.679 ± 13.692* |
| MRT0-∞ (h) | 20.012 ± 4.27 | 15.224 ± 0.92* | 16.967 ± 1.305 |
| F (%) | 100 | 151 | 194.7 |
*p < 0.05 when compared to the free drug; **p < 0.001 when compared to the free drug.