Figure 2.
Norepinephrine transporter inhibitor mechanism of action. In the sinus node sympathetic synapse blocking norepinephrine reuptake increases intrasynaptic norepinephrine levels. Alpha and beta symbols denote subtypes of adrenergic receptors. DHPG = dihydroxyphenylglycol; L-DOPA = L-3,4 dihydroxyphenylalanine; MAO = monamine oxidase; NET = norepinephrine transporter; VMAT 2 = vesicular monoamine transporter 2.