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. 2024 Jun 20;10(9):639–643. doi: 10.1016/j.hrcr.2024.06.009

Table 1.

Symptoms and implantable loop recorder recordings

Day State Symptoms Trough rhythm and rate Therapy
0 ILR implanted Sinus rhythm None
1 Sleep Sleep syncope 35.6 s pause None
9 Sleep Asleep 27 s pause Atomoxetine 40 mg daily
10 Awake Presyncope 40 bpm for 16 s Atomoxetine 40 mg bid
32 Awake Presyncope 40 bpm for 30 s Atomoxetine 40 mg bid
33 Awake Presyncope ×3 50 bpm 50 s Atomoxetine 40 mg bid
34 Awake Presyncope 42 bpm 42 s Atomoxetine 40 mg bid
70 Awake Presyncope 75 bpm 30 s Atomoxetine 40 mg bid
72 Awake Presyncope 60 bpm 30 s Atomoxetine 40 mg bid
73 Awake Presyncope 54 bpm 20 s Atomoxetine 40 mg bid
112 Awake Presyncope 33 bpm Atomoxetine 40 mg bid
114 Asleep Asleep 5 s sinus pause Atomoxetine 40 mg bid
114 Asleep Asleep 6 s sinus pause Atomoxetine 40 mg bid
129 Awake Presyncope ×3 Mobitz 1 2nd degree AV block Atomoxetine 40 mg bid
131 Asleep Presyncope ×2 10 s 2nd degree AV block Atomoxetine 40 mg bid
133 Awake, supine Presyncope 2nd degree AV block Atomoxetine 40 mg bid

AV = atrioventricular; bid = twice a day; bpm = beats per minute; ILR = implantable loop recorder.

The suppression of vagal asystole was associated with atomoxetine 40 bid (P = .032, Fisher exact). There was no sleep syncope and a reduction in asystole while taking atomoxetine 40 mg bid.