Table 1.
Day | State | Symptoms | Trough rhythm and rate | Therapy |
---|---|---|---|---|
0 | ILR implanted | Sinus rhythm | None | |
1 | Sleep | Sleep syncope | 35.6 s pause | None |
9 | Sleep | Asleep | 27 s pause | Atomoxetine 40 mg daily |
10 | Awake | Presyncope | 40 bpm for 16 s | Atomoxetine 40 mg bid |
32 | Awake | Presyncope | 40 bpm for 30 s | Atomoxetine 40 mg bid |
33 | Awake | Presyncope ×3 | 50 bpm 50 s | Atomoxetine 40 mg bid |
34 | Awake | Presyncope | 42 bpm 42 s | Atomoxetine 40 mg bid |
70 | Awake | Presyncope | 75 bpm 30 s | Atomoxetine 40 mg bid |
72 | Awake | Presyncope | 60 bpm 30 s | Atomoxetine 40 mg bid |
73 | Awake | Presyncope | 54 bpm 20 s | Atomoxetine 40 mg bid |
112 | Awake | Presyncope | 33 bpm | Atomoxetine 40 mg bid |
114 | Asleep | Asleep | 5 s sinus pause | Atomoxetine 40 mg bid |
114 | Asleep | Asleep | 6 s sinus pause | Atomoxetine 40 mg bid |
129 | Awake | Presyncope ×3 | Mobitz 1 2nd degree AV block | Atomoxetine 40 mg bid |
131 | Asleep | Presyncope ×2 | 10 s 2nd degree AV block | Atomoxetine 40 mg bid |
133 | Awake, supine | Presyncope | 2nd degree AV block | Atomoxetine 40 mg bid |
AV = atrioventricular; bid = twice a day; bpm = beats per minute; ILR = implantable loop recorder.
The suppression of vagal asystole was associated with atomoxetine 40 bid (P = .032, Fisher exact). There was no sleep syncope and a reduction in asystole while taking atomoxetine 40 mg bid.