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MRI of GM1 patients. Axial MPRAGE, T2, and FLAIR images are shown at the same level for a representative late-infantile (top) and juvenile (bottom) patient. While both cases demonstrate marked degeneration, the late-infantile patients were more severe, adding difficulty when generating regions of interest (ROIs). ROIs for each brain structure were determined based on the MPRAGE or 3D FFE images given the overall clarity of the structures.
